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RDBiomed Limited

UK and Rest of World
RDBiomed Ltd
Daisy Building (2nd Floor)
Castle Hill Hospital, Castle Road
HU16 5JQ
United Kingdom
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General: +44 (0) 1482 461877

Business: +44 (0) 1482 461880

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Biohit HealthCare Srl

Exclusive Distributor throughout Europe
Via Boncompagni, 3
20129 Milano (MI)

Phone: +39 02.38238113

Fax: +39 02.38236521


Peptest™ Overview
Peptest™ is the world’s first non-invasive diagnostic for
reflux disease.

Peptest™ can be used to identify the presence of pepsin, which can contribute to the pathology of a wide spectrum of conditions:

  • GORD
  • EOR
  • LPR
  • Chronic cough
  • Cystic fibrosis
  • Lung allograft rejection
  • Otitis media with effusion
  • Asthma
  • Sinusitis

Peptest™ can detect pepsin in a wide range of clinical samples including:

  • Saliva
  • Sputum
  • Tracheal aspirate
  • Oesophageal aspirate
  • Gastric juice (Requires Dilution)
  • Exhaled breath condensate
  • Bronchoalveolar lavage fluid

How the industry currently
detects the presence of pepsin

Gastric juice comprises ingested food and drink, acid and the digestive enzyme pepsin. All these components can be refluxed from the stomach into the oesophagus, larynx and respiratory system. Reflux of gastric juice is usually identified by detecting refluxed acid (H+ions) using 24 hr pHmetry or detecting refluxed fluid using 24 hr impedance monitoring. Both these techniques are highly invasive and in the case of pHmetry require the gastric fluid to be < pH 4.

So, why use Peptest™ ?

Peptest™ permits the non-invasive, pH independent identification of patients suffering from gastric reflux. It detects pepsin in clinical samples obtained from the upper digestive tract and the respiratory system. The presence of pepsin in these samples is a reliable marker for the reflux of gastric juice.

Pepsin is the enzyme responsible for the crude digestion of protein in the diet. It is also the main aggressive agent responsible for damaging oesophageal and laryngeal tissue during reflux. Detection of pepsin in the refluxate is an appropriate objective clinical measurement tool because it specifically detects the damaging component of gastric refluxate.

Furthermore, detection of pepsin and the identification of a reflux event is independent of the pH of gastric fluid.